Who Are Pfizer’s (PFE) Main Competitors?

Pfizer Inc. (PFE) is a leading global biopharmaceutical company based in New York. The company makes money by developing and manufacturing drug treatments to promote health and prevent disease. Its single operating segment spans a range of therapeutic areas, including oncology, internal medicine, hospital, vaccines, inflammation and immunology, and rare diseases. In FY 2022, Pfizer generated $31.37 billion in net income out of $100.33 billion in annual revenue. The company’s market capitalization was $227 billion as of market close on Mar. 24, 2023.

Pfizer’s best-selling drugs in FY 2022 were: Comirnaty, an immunization designed to prevent COVID-19 in people 12 or older, which generated $37.8 billion in revenue; Ipaxlovid, an antivirus that targets specific parts of the COVID-19 virus to keep it from multiplying in the body of people who are more at risk of getting very sick, which brought in $18.9 billion; and Eliquis, used to treat nonvalvular atrial fibrillation, deep vein thrombosis, and pulmonary embolism, and which generated $6.5 billion.

Several other large, global drug manufacturers present Pfizer with significant competition. They include Johnson & Johnson (JNJ), Roche Holding AG (RHHBY), Eli Lilly and Co. (LLY), AbbVie Inc. (ABBV), Novo Nordisk (NVO), and Merck & Co. (MRK). We take a closer look at these six pharmaceutical industry giants below. They are ranked by market cap as of the close of trading on Mar. 24, 2023. Roche Holdings’ and Novo Nordisk’s revenue for specific drugs were converted from Swiss francs and Danish kroner to U.S. dollars on Mar. 25, 2023.

• Market Cap: $397.5 billion
• FY 2022 Revenue: $95 billion
• FY 2022 Net Income: $17.9 billion
• Top Drug by Revenue (FY 2022): Darzalex
• Revenue from Top Drug (FY 2022): $7.9 billion

Johnson & Johnson is well known for its various consumer health products, pharmaceuticals, and medical devices. Its sales results for 2022 were $52.6 billion in pharmaceuticals, $37.4 billion in medical devices, and $14.9 billion in medical devices.

• Market Cap: $343.2 billion
• FY 2022 Revenue: $50.5 billion
• FY 2022 Net Income: $6.9 billion
• Top Drug by Revenue (FY 2022): Ozempic
• Revenue from Top Drug (FY 2022): $8.6 billion

Novo Nordisk is a Danish pharmaceutical manufacturer that focuses on treating diabetes, obesity, and other serious chronic diseases and conditions.

Novo Nordisk’s top-selling drug in 2022 was Ozempic, an insulin therapy delivered by injection. Other top sellers for 2022 were Victoza (injection) and Rybelus, a pill that increases insulin levels in the body to reduce liver sugar production, with combined sales values of $34 billion.

• Market Cap: $319.45 billion
• FY 2022 Revenue: $28.5 billion
• FY 2022 Net Income: $28.5 billion
• Top Drug by Revenue (FY 2022): Trulicity
• Revenue from Top Drug (FY 2022): $5.7 billion

Eli Lilly is a global drug manufacturing company headquartered in Indianapolis, Indiana. Its business focuses on discovering, developing, manufacturing, and marketing human pharmaceutical products. Those products span different therapeutic areas, including diabetes, oncology, immunology, neuroscience, and more.

Eli Lilly’s top-selling drug in FY 2022 was Trulicity, used to treat type 2 diabetes and reduce the risk of significant adverse cardiovascular events. Other top-selling medicines in FY 2022 include:

• Breast cancer treatment drug Verzenio, which generated $1.7 billion
• Taltz, a treatment for plaque psoriasis, which brought in $1.7 billion
• Jardiance, a treatment for type 2 diabetes, which generated $1.2 billion in revenues

• Market Cap: $279.6 billion
• FY 2022 Revenue: $58.1 billion
• FY 2022 Net Income: $58.1 billion
• Top Drug by Revenue (FY 2022): Humira
• Revenue from Top Drug (FY 2022): $18.6 billion

AbbVie is a global biopharmaceutical company based in Chicago. The company’s single business segment is engaged in research and development, manufacturing, commercializing, and selling innovative medicines and therapies. Its products span a range of healthcare-related areas, including immunology, oncology, aesthetics, neuroscience, eye care, women’s health, and more.

AbbVie’s top-selling drug in FY 2022 was Humira, a biologic therapy used to treat several autoimmune diseases, such as rheumatoid arthritis, psoriatic arthritis, adult Crohn’s disease, and others. Other top-selling drugs in FY 2022 include: immunologic drugs Skyrizi, which brought in $4.4 billion in revenue, and Rinvoq, which generated $1.8 billion.

• Market Cap: $266 billion
• FY 2022 Revenue: $58.5 billion
• FY 2022 Net Income: $58.5 billion
• Top Drug by Revenue (FY 2022): Keytruda
• Revenue from Top Drug (FY 2022): $20.9 billion

Merck is a global healthcare company based in Kenilworth, New Jersey. The company offers prescription medicines, vaccines, biologic therapies, and animal health products. Its two operating segments are pharmaceutical and animal health. It offers a variety of treatments across a wide range of areas, including oncology, vaccines, hospital acute care, immunology, neuroscience, virology, cardiovascular, diabetes, women’s health, livestock products, and companion animal products.

Merck’s top-selling drug in FY 2022 was Keytruda, which is used to treat patients with a range of different types of cancer, such as cervical cancer, classical Hodgkin Lymphoma, certain lung cancers, and numerous others.

Other top-selling drugs in FY 2022 include: COVID-19 anti-viral drug Lagevria, which brought in $5.7 billion of revenue; and Human Papillomavirus vaccines Gardasil/Gardasil 9, which generated $6.9 billion in revenue.

• Market Cap: $227.5 billion
• FY 2022 Revenue: $66.3 billion
• FY 2022 Net Income: $66.3 billion
• Top Drug by Revenue (FY 2022): Ocrevus
• Revenue from Top Drug (FY 2022): $6.6 billion

Roche Holding AG is the holding company for F. Hoffman-La Roche AG (the pharmaceutical company known as Roche), a global healthcare company headquartered in Basel, Switzerland. Its business is organized into two main divisions: pharmaceuticals and diagnostics. The company develops drugs and treatments across various areas, including oncology, neuroscience, infectious diseases, immunology, cardiovascular and metabolism, ophthalmology, and respiratory.

Roche’s top-selling drug in FY 2022 was Ocrevus, used to treat multiple sclerosis. Oncology drug Perjeta generated $4.4 billion, and hemophilia treatment Hemlibra brought in $4.2 billion.